ALDH18A1 Polyclonal Antibody

China

https://www.ncbi.nlm.nih.gov/gene/5832

For laboratory research and development purposes only.

87kDa

Rabbit

Polyclonal Antibodies

IgG

Affinity purification

Recombinant protein of human ALDH18A1 (NP_002851.2).

P54886

This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene.

WB 1:500 - 1:2000