REST Rabbit pAb

China

For laboratory research and development purposes only.

35kDa/36kDa/119kDa/121kDa

Rabbit

Polyclonal antibody

Rabbit IgG

Affinity purified

Recombinant fusion protein containing a sequence corresponding to amino acids 760-1060 of human REST (NP_001180437.1).

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q13127

REST

Nucleus

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.

IF 1:50 - 1:200(Optimal dilutions should be determined by the end user)