RALA Rabbit pAb

China

For laboratory research and development purposes only.

24kDa

Rabbit

Polyclonal antibody

Rabbit IgG

Affinity purified

Recombinant fusion protein containing a sequence corresponding to amino acids 1-206 of human RALA (NP_005393.2).

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P11233

RALA

Cell membrane, Membrane

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108). Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (PubMed:19306925). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (PubMed:18756269).

WB 1:500 - 1:2000(Optimal dilutions should be determined by the end user)