HP-1γ Mouse mAb (9E5)

China

https://www.ncbi.nlm.nih.gov/gene/11335

9E5-1E3-3A8

For laboratory research and development purposes only.

24kDa

Mouse

Monclonal antibody

IgG1

Affinity purified

Purified recombinant protein expressed in E.coli.

PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.

Q13185

Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitement of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679).

CBX3

Nucleus

WB 1:1,000-2,000 IHC 1:100-200 (Optimal dilutions should be determined by the end user)