Specifications
GENE ID
https://www.ncbi.nlm.nih.gov/gene/10891;
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
REACTIVITY SPECIES
Hu Ms Rt
PURIFICATION
Antigen affinity purification.
IMMUNOGEN
Synthetic peptide corresponding to a region derived from internal residues of human peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
SPECIFICITY
The antibody detects endogenous levels of total PPARGC1A protein.
BACKGROUND
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination.?
ALTERNAME
LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1(alpha)
FORM OF ANTIBODY
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
RECOMMENDED DILUTIONS
Western blotting: 1:200-1:1000<br/>
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