Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
Specifications
COUNTRY OF ORIGIN
China
GENE ID
https://www.ncbi.nlm.nih.gov/gene/29947;
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
APPLICATION.1
IHC
ANTIBODY TYPE
Polyclonal
HOST SPECIES
Rabbit
REACTIVITY SPECIES
Hu
PURIFICATION
Antigen affinity purification.
GENE ALIAS
DNMT3L
IMMUNOGEN
Fusion protein corresponding to residues near the C terminal of human DNA (cytosine-5-)-methyltransferase 3-like
SPECIFICITY
The antibody detects endogenous levels of total DNMT3L protein.
SWISS-PROT NO.
Q9UJW3
BACKGROUND
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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