Specifications
GENE ID
https://www.ncbi.nlm.nih.gov/gene/56650;
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
PURIFICATION
Antigen affinity purification.
IMMUNOGEN
Fusion protein corresponding to a region derived from internal residues of human claudin domain containing 1
SPECIFICITY
The antibody detects endogenous levels of total CLDND1 protein.
BACKGROUND
CLDND1 (claudin domain containing 1), also known as C3orf4 or HSPC174, is a 253 amino acid multi-pass membrane protein that is expressed at high levels in adult brain and at lower levels in adult heart. Existing as two alternatively spliced isoforms, CLDND1 is encoded by a gene that maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.
ALTERNAME
C3orf4; GENX-3745
FORM OF ANTIBODY
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
RECOMMENDED DILUTIONS
Immunohistochemistry: 1:50-1:200
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