Specifications
GENE ID
https://www.ncbi.nlm.nih.gov/gene/4071;
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
PURIFICATION
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
IMMUNOGEN
Synthesized peptide derived from internal of human T4S1.
SPECIFICITY
The antibody detects endogenous levels of total T4S1 protein.
BACKGROUND
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas.<br/><br/>Marken J.S., Proc. Natl. Acad. Sci. U.S.A. 89:3503-3507(1992).<br/>The MGC Project Team, Genome Res. 14:2121-2127(2004).<br/>Marken J.S., J. Biol. Chem. 269:7397-7401(1994).<br/>
ALTERNAME
Transmembrane 4 L6 family member 1; Tumor-associated antigen L6; Membrane component surface marker 1; M3S1; TM4SF1
FORM OF ANTIBODY
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
RECOMMENDED DILUTIONS
<br/>Immunohistochemistry: 1:50~1:100<br/>
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