ERCC5 Antibody

China

For laboratory research and development purposes only.

130kd

WB

Rabbit

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Synthesized peptide derived from internal of human ERCC5.

https://www.ncbi.nlm.nih.gov/gene/2073;

Polyclonal

ERCC5

The antibody detects endogenous levels of total ERCC5 protein.

<p>Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.<br /> <br /> Scherly D., Nature 363:182-185(1993).<br /> Shiomi T., Mutat. Res. 314:167-175(1994).<br /> Macinnes M.A., Mol. Cell. Biol. 13:6393-6402(1993).</p>

P28715

DNA excision repair protein ERCC-5; DNA-repair protein complementing XP-G cells; ERCC5; XPGC; Xeroderma pigmentosum group G complementing protein

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Western blotting: 1:500~1:3000</p>