TEAD1 Antibody

China

https://www.ncbi.nlm.nih.gov/gene/7003;

For laboratory research and development purposes only.

48kd

WB IHC IF

Polyclonal

Rabbit

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

TEAD1

Synthesized peptide derived from Internal of human TEAD1.

The antibody detects endogenous levels of total TEAD1protein.

P28347

<p>Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.<br /> <br /> Xiao J.H., Cell 65:551-568(1991).<br /> Taylor T.D., Nature 440:497-500(2006).<br /> Olsen J.V., Cell 127:635-648(2006).</p>

AA; atrophia areata; peripapillary chorioretinal degeneration; NTEF-1; Protein GT-IIC

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Western blotting: 1:500~1:3000<br /> IHC:&nbsp;1:50-1:200</p> IF&nbsp;1:100-1:500</p>