Neferine is an alkaloid that has been found in N. nucifera and has diverse biological activities. It inhibits ADP-, collagen-, thrombin-, U46619-, or adrenaline-induced aggregation of isolated human platelets when used at a concentration of 3 µM. Neferine (2 µM) prevents LPS- and ATP-induced pyroptosis, NLRP3 inflammasome activation, and the production of reactive oxygen species (ROS) in human umbilical vein endothelial cells (HUVECs). It decreases expression of the genes encoding peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer-binding protein α (C/EBPα), sterol regulatory...
Neferine is an alkaloid that has been found in N. nucifera and has diverse biological activities. It inhibits ADP-, collagen-, thrombin-, U46619-, or adrenaline-induced aggregation of isolated human platelets when used at a concentration of 3 µM. Neferine (2 µM) prevents LPS- and ATP-induced pyroptosis, NLRP3 inflammasome activation, and the production of reactive oxygen species (ROS) in human umbilical vein endothelial cells (HUVECs). It decreases expression of the genes encoding peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer-binding protein α (C/EBPα), sterol regulatory...
Shipping & Handling
Shipped In
Room Temperature in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
Room Temperature in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
Regulatory & Compliance
We’re currently in BETA - Interested in joining? Let us know and we’ll get you set up with early access.
We’re currently in BETA - Interested in joining? Let us know and we’ll get you set up with early access.