GNE-6640 is an inhibitor of ubiquitin-specific protease 7 (USP7; IC50 = 0.75 µM). It is selective for USP7 over USP47 and USP5 (IC50s = 20.3 and >200 µM, respectively). GNE-6640 enhances ubiquitination of the USP7 substrate MDM2 in HCT116 colon cancer cells (IC50 = 0.23 µM) and reduces cell viability in a panel of 108 cell lines (IC50s = <10 µM for all). GNE-6640 (10-70 µM) enhances apoptosis induced by doxorubicin (Item No. 15007) or cisplatin (Item No. 13119) in MCF-7 and U2OS cancer cells, respectively.
GNE-6640 is an inhibitor of ubiquitin-specific protease 7 (USP7; IC50 = 0.75 µM). It is selective for USP7 over USP47 and USP5 (IC50s = 20.3 and >200 µM, respectively). GNE-6640 enhances ubiquitination of the USP7 substrate MDM2 in HCT116 colon cancer cells (IC50 = 0.23 µM) and reduces cell viability in a panel of 108 cell lines (IC50s = <10 µM for all). GNE-6640 (10-70 µM) enhances apoptosis induced by doxorubicin (Item No. 15007) or cisplatin (Item No. 13119) in MCF-7 and U2OS cancer cells, respectively.
Shipping & Handling
Shipped In
Room Temperature in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
Room Temperature in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
Regulatory & Compliance
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We’re currently in BETA - Interested in joining? Let us know and we’ll get you set up with early access.