Fursultiamine

Fursultiamine is a synthetic derivative of vitamin B1 (thiamine; Item No. 25332). It reduces LPS-induced increases in IL-6, IL-8, and chemokine (C-C motif) ligand 2 (CCL2) protein levels and decreases in mitochondrial respiration in ARPE-19 retinal pigment epithelial cells when used at concentrations of 100 and 20 µM, respectively. Fursultiamine (50 mg/kg) also reduces the area and severity of laser-induced lesions in a mouse model of choroidal neovascularization (CNV). It increases thiamine levels in various rat tissues, including skeletal muscle and the heart, and prevents physical-fatigue loading...