Halicin is a JNK1 inhibitor (IC50 = 0.7 µM). It is selective for JNK1 over p38α, Furin, and lethal factor (IC50s = >100, >100, and >50 µM, respectively), as well as Akt at 100 µM. Halicin inhibits TNF-α-induced phosphorylation of c-Jun in a cell-based assay (EC50 = 6.23 µM). In vivo, halicin (25 mg/kg) reduces blood glucose levels and restores insulin sensitivity in insulin insensitive mice. Halicin is active against carbapenem-resistant Enterobacteriaceae (MICs = 1-10 µg/ml), as well as multidrug-resistant A. baumannii and P. aeruginosa (MICs = 1-10 and 1-100 µg/ml, respectively). It reduces...
Halicin is a JNK1 inhibitor (IC50 = 0.7 µM). It is selective for JNK1 over p38α, Furin, and lethal factor (IC50s = >100, >100, and >50 µM, respectively), as well as Akt at 100 µM. Halicin inhibits TNF-α-induced phosphorylation of c-Jun in a cell-based assay (EC50 = 6.23 µM). In vivo, halicin (25 mg/kg) reduces blood glucose levels and restores insulin sensitivity in insulin insensitive mice. Halicin is active against carbapenem-resistant Enterobacteriaceae (MICs = 1-10 µg/ml), as well as multidrug-resistant A. baumannii and P. aeruginosa (MICs = 1-10 and 1-100 µg/ml, respectively). It reduces...
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Room Temperature in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
Room Temperature in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
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