Garcinol is a polyisoprenylated benzophenone that has been found in G. indica and has diverse biological activities. It inhibits the histone acetyltransferases (HATs) p300 and p300/CREB-binding protein-associated factor (PCAF; IC50s = ~7 and ~5 µM, respectively), as well as COX-1, microsomal prostaglandin E2 (PGE2) synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO; IC50s = 12, 0.1, and 0.3 µM, respectively). Garcinol (0.8 µM) is active against the fungus C. neoformans in vitro. It scavenges hydroxyl radicals and superoxide anions in cell-free assays and potentiates cytotoxicity and apoptosis induced...
Garcinol is a polyisoprenylated benzophenone that has been found in G. indica and has diverse biological activities. It inhibits the histone acetyltransferases (HATs) p300 and p300/CREB-binding protein-associated factor (PCAF; IC50s = ~7 and ~5 µM, respectively), as well as COX-1, microsomal prostaglandin E2 (PGE2) synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO; IC50s = 12, 0.1, and 0.3 µM, respectively). Garcinol (0.8 µM) is active against the fungus C. neoformans in vitro. It scavenges hydroxyl radicals and superoxide anions in cell-free assays and potentiates cytotoxicity and apoptosis induced...
Shipping & Handling
Shipped In
Wet ice in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
Regulatory & Compliance
We’re currently in BETA - Interested in joining? Let us know and we’ll get you set up with early access.