PHD4 (PH4, PH-4, Prolyl Hydroxlase Domain-containing 4, Prolyl Hydroxylase 4, HIF Prolyl Hydroxylase 4, HIFPH4, Hypoxia-inducible Factor Prolyl 4-hydroxylase, HIF Prolyl 4-hydroxylase, FLJ20262, Hypoxia Inducible Factor Prolyl Hydroxylase, P4H with Transmembrane Domain, P4H-TM, Proline 4 Hydroxylase, Prolyl 4-hydroxylase)

Prolyl hydroxylase 4 is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the prolyl hydroxylase sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. Prolyl hydroxylase is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, prolyl hydroxylases convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low...