FGFR1 (Y766) (Basic Fibroblast Growth Factor Receptor 1, FGFR-1, bFGF-R, Proto-oncogene c-Fgr, Fms-like Tyrosine Kinase 2, FLT-2, CD331, FGFBR, FLG, FLT2) (AP)

FGFR1 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately...