CD10, CT (Atriopeptidase, CALLA, CD 10, Common Acute Lymphocytic Leukemia Antigen, Enkephalinase, EPN, gp100, Membrane Metalloendopeptidase, MME, Neprilysin, NEP, Neutral Endopeptidase 24.11, Pmel17)

MME is a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a oprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues...