SP140 (Sp140 Nuclear Body Protein, LYSP100-B, LYSP100-A, Lymphoid-restricted homolog of Sp100, Nuclear autoantigen Sp-140, Speckled 140kD)

The N terminus of SP140, between 29aa and 157aa, is 49% identical to a corresponding N-terminal region of SP100. The C terminus of SP140 contains a cysteine-rich zinc finger motif and a bromodomain. SP140 also has a central nuclear localization signal. RNA dot blot analysis detected high SP140 expression in spleen and peripheral blood leukocytes, with much lower levels in thymus, prostate, ovary, small intestine, and colon; other tissues showed little to no expression. Low expression of a smaller transcript was also observed. Western blot analysis with PBC autoantibodies detected SP140 at an apparent...