DHDH (Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase, D-xylose 1-Dehydrogenase, D-xylose-NADP Dehydrogenase, Dimeric Dihydrodiol Dehydrogenase, Hum2DD, 2DD)

DHDH (trans-1,2-dihydrobenzene-1,2-diol dehydrogenase), also known as 2DD, D-xylose 1-dehydrogenase, D-xylose-NADP dehydrogenase or dimeric dihydrodiol dehydrogenase, is a 334aa protein belonging to the gfo/idh/mocA family. DHDH catalyzes the NADP(+)-linked oxidation of trans-dihydrodiols of aromatic hydrocarbons to the corresponding catechols. DHDH also catalyzes the conversion of D-xylose and NADP(+) to D-xylono-1,5-lactone and NADPH. Expressed in small intestine, DHDH forms a homodimer. The gene encoding DHDH maps to human chromosome 19q13.33 and mouse chromosome 7 B4. Human chromosome 19 consists...