AHCYL1 (Adenosylhomocysteinase 2, AdoHcyase 2, DC-expressed AHCY-like Molecule, IP(3)Rs binding Protein released with IP(3), IRBIT, S-adenosyl-L-Homocysteine Hydrolase 2, S-adenosylhomocysteine Hydrolase-like Protein 1, AHCYL1, DCAL, IRBIT, XPVKONA)

AHCYL1 (S-adenosylhomocysteine hydrolase-like 1), also known as DCAL, IRBIT or PRO0233, is an endoplasmic reticulum (ER) protein that is involved in amino acid biosynthesis. Expressed in dentritic blood cells (DCs), AHCYL1 functions to catalyze the H(2)O-dependent conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine, a reaction that uses NAD as a cofactor. Additionally, AHCYL1 contains a PDZ-binding domain and a PEST region through which it can interact with IP3R-I (inositol 1,4,5-trisphosphate (IP3) receptor-I), a protein involved in various signaling pathways. This interaction...