CD49d (VLA-4, Integrin a4, VLA-4a, ITGA4, IA4) (PE)

CD49d, a member of the integrin family of extracellular matrix and cell adhesion molecules, is the integrin a4 chain. CD49d associates noncovalently with CD29, the integrin b1 subunit, to form the a4b1 very late antigen-4 (VLA-4) heterodimer. Integrin a4 can also associate with integrin b7 to form the a4b7 heterodimer. It is expressed on most leukocytes, with the possible exception of neutrophils. VLA-4 mediates leukocyte binding to CD106/VCAM-1, and is involved in the migration of leukocytes from blood to tissue at sites of inflammation. VLA-4 can also provide a costimulatory signal to T cells...