TDAG51 (Pleckstrin Homology-like Domain Family A Member 1, Apoptosis-Associated Nuclear Protein, Proline- and glutamine-Rich Protein, PQ-Rich Protein, PQR Protein, Proline- and histidine-Rich Protein, T-Cell Death-Associated Gene 51 Protein, PHLDA1, PHRIP, TDAG51)

Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immunosurveillance against virus-infected or -transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (APO-1) and its ligand (FAS-L). The human FAS (APO-1) protein is a 48kD cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed...