SSRP1 (FACT Complex Subunit SSRP1, Chromatin-specific Transcription Elongation Factor 80kD Subunit, Facilitates chromatin Transcription Complex 80kD Subunit, FACT 80kD Subunit, FACTp80, Facilitates chromatin Transcription Complex Subunit, SSRP1, Recombination Signal Sequence recognition Protein 1, Structure-specific recognition Protein 1, hSSRP1, T160, SSRP1, FACT80)

Expression of protein-coding genes requires the association of specific transcription factors, RNA polymerase and various accessory factors (1). These accessory factors are distinguished as either histone acetyltransferases or ATP-dependent chromatin-remodeling enzymes, which include FACT (for facilitates chromatin transcription), and they facilitate transcription initiation on DNA packaged into chromatin. FACT is a chromatin-specific elongation factor required for transcription of chromatin templates, and it specifically interacts with nucleosomes and histone H2A/H2B dimers, to promote nucleosome...