GCLM (Glutamate-cysteine Ligase, Modifier Subunit, Gamma-glutamylcysteine Synthetase)

GCLM (Glutamate-cysteine ligase, modifier subunit), also known as gamma-glutamylcysteine synthetase, is first rate limiting enzyme of glutathione synthesis. GCLM is heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic antioxidants, heat shock, oxidants and cytokines. GCLM deficiency has been implicated in some forms of hemolytic anemia. Also, GCLM is a molecular target for amelioration of cisplatin restance in lung cancer. Applications: Suitable for use in ELISA, Western Blot. Other applications not tested. Recommended Dilution: Western...