Calpain 10 (Calpain-10, Calcium Activated Neutral Protease, Calcium Activated Neutral Proteinase 10, CANP 10, CAPN 10, CAPN10, EC 3.4.22, KIAA1845, NIDDM1) (HRP)

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead...