HDAC Fluorometric Assay kit

Histones are the chief protein components of chromatin. Modification of histone proteins through acetylation and deacetylation affects chromatin structure and regulates gene expression. Histone hyperacetylation is well correlated with increased transcription, whereas hypoacetylation correlates with transcriptional repression. Histone deacetylases (HDACs), catalyze the removal of acetyl groups from an N-acetyl lysine amino acid on a histone, generally resulting in transcriptional silencing. Histone deacetylases have been grouped into four classes.