Sodium Cyanoborohydride [Reducing Agent]

Japan

Reductive Amination: Borch Reaction Typical Procedure: To a stirred solution of N-ethylbenzylamine (675 mg, 5 mmol) and 37% aqueous formaldehyde (2 mL, 25 mmol) in acetonitrile (15 mL) is added sodium cyanoborohydride (500 mg, 8 mmol). A vigorous exothermic reaction ensues, and a dark residue separates. The reaction mixture is stirred for 15 min, and then glacial acetic acid is added dropwise until the solution tests neutral on wet pH paper. Stirring is continued for an additional 45 min, glacial acetic acid being added occasionally to maintain the pH near neutrality. The solvent is evaporated at reduced pressure, and 2 N KOH (20 mL) is added to the residue. The resulting mixture is extracted with ether (3 × 20 mL). The combined ether extracts are washed with 0.5 N KOH (20 mL) and then extracted with 1 N HCl (3 × 10 mL). The acid extracts are combined and neutralized with solid KOH and then extracted with ether (3 × 20 mL). The combined ether extracts are dried (K2CO3) and evaporated in vacuo to give N-methyl-N-ethylbenzylamine (735 mg, Y. 98%) as a colorless, GPLC-pure oil.

MFCD00003516

87575903.0

4152656.0

GHS05, GHS06, GHS09, GHS02

Danger

H300 + H310 + H330 : Fatal if swallowed, in contact with skin or if inhaled. H314 : Causes severe skin burns and eye damage. H410 : Very toxic to aquatic life with long lasting effects. H260 : In contact with water releases flammable gases which may ignite spontaneously.

P501 : Dispose of contents/ container to an approved waste disposal plant. P223 : Do not allow contact with water. P273 : Avoid release to the environment. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P262 : Do not get in eyes, on skin, or on clothing. P231 + P232 : Handle under inert gas. Protect from moisture. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P284 : Wear respiratory protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P335 + P334 : Brush off loose particles from skin. Immerse in cool water/ wrap in wet bandages. P391 : Collect spillage. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P362 : Take off contaminated clothing and wash before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P350 + P310 : IF ON SKIN: Gently wash with plenty of soap and water. Immediately call a POISON CENTER or doctor/ physician. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P402 + P404 : Store in a dry place. Store in a closed container. P405 : Store locked up.

4.3/6.1

II

UN3134

8606.0

For laboratory research and development purposes only.

>95.0%(T)

Solid

62.84

Fukaya factory is certified for GMP, ISO14001:2004 (JQA-EM5386) and IQ Net (JP-JQA-EM5386).

White to Almost white powder to crystal

CH3BNNa

2837.20.5100

>95.0%(T)