(Pentamethylcyclopentadienyl)rhodium(III) Dichloride Dimer

C-H Activation [Catalysis]

Rhodium Compounds [C-H Activation]

Japan

Cp*-Rh catalyzed oxidative Heck reaction Cp*-Rh catalyzed Direct Ar-H Sulfonamidation and Amination Reactions Rhodium-catalyzed Annulation of N-Benzoylsulfonamide with Isocyanide through C―H Activation Typical Procedure: N-Benzoyl-4-methylbenzenesulfonamide (27.5 mg, 0.1 mmol), [RhCl2Cp*]2 (1.2 mg, 0.002 mmol) and Cu(OAc)2·H2O (40.0 mg, 0.2 mmol) are loaded in a dry vial which is subjected to evacuation/flushing with dry argon three times. A solution of 2,6-dimethylphenyl isocyanide (19.6 mg, 0.15 mmol) in anhydrous dichloroethane (0.8 mL) is syringed into the mixture that is then stirred at 130 °C for 20 h or until the starting material has been consumed as determined by TLC. Upon cooling to room temperature, all volatiles are evaporated and the residue is purified by preparative TLC (ethyl acetate : hexane = 1 : 2) to give the corresponding 3-(imino)isoindolinone derivative (Y. 70%, E/Z = 3 : 1). Z and E isomers are further separated by preparative TLC (methylene chloride : hexane = 10 : 1).

MFCD00061552

87560640.0

GHS07

Warning

H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation.

P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.

For laboratory research and development purposes only.

>96.0%(T)

Solid

618.07

Fukaya factory is certified for GMP, ISO14001:2004 (JQA-EM5386) and IQ Net (JP-JQA-EM5386).

Light yellow to Brown powder to crystal

C20H30Cl4Rh2

min. 96.0 %

2931.90.6000

>96.0%(T)