Specifications
CLASS
Chemical Shift Standards for NMR
APPLICATION
Trimethylsilylating Reagent
Typical Procedure (Entry 1):
In a 100 mL flask equipped with a Dean-Stark trap are placed hexanoic acid (17.5 g, 151 mmol), hexamethyldisiloxane (48.7 g, 301 mmol), sulfuric acid (1.5 g, 15 mmol), and toluene (40 mL). The flask is then heated to gentle reflux, and the course of the reaction is monitored by GLC. After 72 h, the reaction mixture is distilled under reduced pressure to give trimethylsilyl hexanoate (20.2 g, Y. 71%) as a colorless liquid.
PUBCHEM SUBSTANCE ID
87570539.0
BEILSTEIN/REAXYS NUMBER
1736258.0
GHS PICTOGRAM CODES
GHS07, GHS02
HAZARD STATEMENTS
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H413 : May cause long lasting harmful effects to aquatic life.
H225 : Highly flammable liquid and vapor.
PRECAUTIONARY STATEMENTS
P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
P240 : Ground/bond container and receiving equipment.
P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking.
P233 : Keep container tightly closed.
P243 : Take precautionary measures against static discharge.
P241 : Use explosion-proof electrical/ ventilating/ lighting/ equipment.
P242 : Use only non-sparking tools.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
P403 + P235 : Store in a well-ventilated place. Keep cool.
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
QUALITY CERTIFICATION / COMPLIANCE
Fukaya factory is certified for GMP, ISO14001:2004 (JQA-EM5386) and IQ Net (JP-JQA-EM5386).
APPEARANCE
Colorless to Almost colorless clear liquid
MOLECULAR FORMULA
C6H18OSi2
SDBS (AIST SPECTRAL DB)
5566.0
PURITY / ANALYSIS METHOD
>98.0%(GC)
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