G418: A Selective Agent for Genetically Engineered Eukaryotic Cells
G418 is an aminoglycoside antibiotic similar in structure to gentamicin [G0383] and is frequently used to selective agent for genetically engineered eukaryotic cells after transfection or transduction. It binds with the 70s and 80s ribosomes, and then it inhibits eukaryotic cell growth by inhibiting protein synthesis.
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