Specifications
CLASS
Vitamins and Related Compounds
SUBCLASS
Vitamin Derivatives
APPLICATION
Etretinate: A Synthetic Retinoic Acid Derivative that is a Prodrug of Acitretin
Etretinate is a retinoic acid (vitamin A acid) [R0064] derivative that is a prodrug of acitretin [A3097]. Etretinate is used for the treatment of severe psoriasis and other dyskeratoses, but the precise mechanism of action of it is not fully understood. However, the pharmacological profile of etretinate suggests that it acts by normalizing pathological changes in epidermal and dermal skin, particularly inhibiting hyperkeratinization and cell differentiation. In addition, etretinate reportedly has teratogenic potential. (The product is for research purpose only.)
PUBCHEM SUBSTANCE ID
468591705.0
BEILSTEIN/REAXYS NUMBER
2225606.0
GHS PICTOGRAM CODES
GHS07, GHS08, GHS09
HAZARD STATEMENTS
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H360 : May damage fertility or the unborn child.
H410 : Very toxic to aquatic life with long lasting effects.
PRECAUTIONARY STATEMENTS
P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P391 : Collect spillage.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
P405 : Store locked up.
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
QUALITY CERTIFICATION / COMPLIANCE
Fukaya factory is certified for GMP, ISO14001:2004 (JQA-EM5386) and IQ Net (JP-JQA-EM5386).
APPEARANCE
White to Yellow to Green powder to crystal
MOLECULAR FORMULA
C23H30O3
PURITY (HPLC)
min. 98.0 area%
PURITY / ANALYSIS METHOD
>98.0%(HPLC)
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