Dansylamide [for Albumin binding assay]

Albumin Binding Agents

Albumin Binding Fluorescent Probes

Japan

Fluorescent Probes for the Characterization of Two Specific Drug Binding Sites on HSA Human Serum Albumin (HSA) binds to a wide variety of drugs at two primary binding sites (I: blue and II: yellow), and can have a significant impact on their pharmacokinetics and pharmacological effects. The fluorescent probes, dansylamide (1) and dansylglycine (2) selectively interact with sites I and II, respectively.1,2) BD140 (3) also binds to drug binding site II specifically.3) Changes in probe fluorescence are analyzed by fluorescence titrations as a result of competitive displacient by drugs and pharmaceuticals. The pattern of fluorescent probe displacient by these reagents enabled the identification of two specific drug binding sites, which illustrates their usefulness for the characterization of the binding sites in HSA. Specific fluorescent probe binding to drug binding site 1 on human serum albumin (HSA)

MFCD00004000

354335223.0

2217203.0

For laboratory research and development purposes only.

>98.0%(T)

Solid

250.32

Fukaya factory is certified for GMP, ISO14001:2004 (JQA-EM5386) and IQ Net (JP-JQA-EM5386).

White to Light yellow powder to crystal

C12H14N2O2S

11148.0

2935.90.9500

>98.0%(T)