Specifications
CLASS
Chiral Catalysts, Chiral Ligands, Chiral Reagents
SUBCLASS
Proline-Based Organocatalysts [Asymmetric Synthesis]
APPLICATION
Organocatalysts for Asymmetric Michael Additional Reactions
Asymmetric Organocatalyst
Experimental procedure3): The β-ketoester 2 (0.2 mmol) is added to a solution of 3 (0.02 mmol), benzoic acid (0.02 mmol), and the aldehyde 1 (0.6 mmol) in toluene (0.2 mL). After complete consumption of 2, usually within 14–18 h, the crude product is directly charged on to silica gel and subjected to flash chromatography (hexane:Et2O) to afford 4.
PUBCHEM SUBSTANCE ID
354334880.0
BEILSTEIN/REAXYS NUMBER
10089429.0
HAZARD STATEMENTS
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
PRECAUTIONARY STATEMENTS
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
QUALITY CERTIFICATION / COMPLIANCE
Fukaya factory is certified for GMP, ISO14001:2004 (JQA-EM5386) and IQ Net (JP-JQA-EM5386).
APPEARANCE
White to Yellow to Green clear liquid
MOLECULAR FORMULA
C20H27NOSi
PURITY / ANALYSIS METHOD
>98.0%(GC)(T)
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