5'-Deoxy-5-fluorouridine

Nucleosides, Nucleotides, Oligonucleotides

Nucleoside Analogs

Japan

5'-Deoxy-5-Fluorouridine (Doxifluridine): A Prodrug of Active Antitumor 5-FU 5'-Deoxy-5-fluorouridine (doxifluridine) is a prodrug of active antitumor 5-FU [F0151] and an intermediary metabolite of capecitabine [C2878] and 5'-deoxy-5-fluorocytidine [D4342]. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5'-deoxy-5-fluorocytidine and doxifluridine, to form 5-FU. Capecitabine and its intermediary metabolites are not cytotoxic by themselves. The final step (doxifluridine to 5-FU) requires thymidine phosphorylase (dThdPase) that is significantly more active in tumor than normal tissue. This tumor-selective delivery of 5-FU ensured greater efficacy and a more favorable safety profile than with other fluoropyrimidines. (The product is for research purpose only.)

MFCD00866530

87559877.0

890191.0

GHS07, GHS08

Warning

H373 : May cause damage to organs through prolonged or repeated exposure. H317 : May cause an allergic skin reaction.

P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P280 : Wear protective gloves. P272 : Contaminated work clothing must not be allowed out of the workplace. P314 : Get medical advice/ attention if you feel unwell. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P363 : Wash contaminated clothing before reuse.

YU7526000

3437.0

For laboratory research and development purposes only.

>98.0%(T)(HPLC)

Solid

246.19

Fukaya factory is certified for GMP, ISO14001:2004 (JQA-EM5386) and IQ Net (JP-JQA-EM5386).

White to Almost white powder to crystal

C9H11FN2O5

min. 98.0 area%

2934.99.4400

>98.0%(T)(HPLC)