3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one

Coupling [Synthetic Reagents]

Active Esters, Additives [Coupling Reagents]

Japan

A Condensing Agent Experimental procedure: to a solution of 1 (1 eq.), 2 (1 eq.) and DEPBT (1 eq.) in THF, triethylamine (2 eq.) is added. The reaction mixture is stirred at room temperature for 2 h. Saturated NaCl solution is added. The peptide is extracted with EtOAc (3 times). The combined organic layer is washed with 1 mol/L HCl, water, 5% Na2CO3, brine and dried over MgSO4. The solvent is removed under reduced pressure and the resulting residue is recrystallized to afford 3 (94% yield).

87557985.0

7489262.0

GHS07

Warning

H315 : Causes skin irritation. H319 : Causes serious eye irritation.

P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse.

For laboratory research and development purposes only.

>98.0%(HPLC)(N)

Solid

299.22

Fukaya factory is certified for GMP, ISO14001:2004 (JQA-EM5386) and IQ Net (JP-JQA-EM5386).

White to Almost white powder to crystal

C11H14N3O5P

min. 98.0 area%

2933.99.8290

>98.0%(HPLC)(N)