Specifications
CLASS
Coupling [Synthetic Reagents]
SUBCLASS
Phosphonium Salts, Uronium Salts, Formamidinium Salts [Coupling Reagents]
APPLICATION
A Condensing Agent
Experimental procedure2): A solution of 1 (80 mg, 0.189 mmol, 1.0 eq.) in acetonitrile (1.5 mL) and diethylamine (1.5 mL) is stirred at room temperature under N2 for 30 min and then concentrated. The residue is concentrated twice more from acetonitrile and then suspended in CH2Cl2 (3 mL) under N2. To this is added 2 (77 mg, 0.199 mmol, 1.15 eq.), DIPA (82 μL, 0.473 mmol, 2.5 eq.), and BroP (77 mg, 0.199 mmol, 1.05 eq.). The flask is flushed with N2, stoppered, and left to stir at room temperature overnight. The mixture is concentrated and the residue applied to a flash column in a minimum volume of CH2Cl2. The column is eluted with 3:1 EtOAc - hexanes to afford 3 (106 mg, 98% yield).
PUBCHEM SUBSTANCE ID
160870946.0
BEILSTEIN/REAXYS NUMBER
14221932.0
HAZARD STATEMENTS
H314 : Causes severe skin burns and eye damage.
PRECAUTIONARY STATEMENTS
P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dusts or mists.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P363 : Wash contaminated clothing before reuse.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor.
P405 : Store locked up.
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
QUALITY CERTIFICATION / COMPLIANCE
Fukaya factory is certified for GMP, ISO14001:2004 (JQA-EM5386) and IQ Net (JP-JQA-EM5386).
APPEARANCE
White to Almost white powder to crystal
MOLECULAR FORMULA
C6H18BrF6N3P2
PURITY (HPLC)
min. 98.0 area%
PURITY (ARGENTOMETRIC TITRATION)
min. 98.0 %
PURITY / ANALYSIS METHOD
>98.0%(T)(HPLC)
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