Specifications
CLASS
Vitamins and Related Compounds
SUBCLASS
Vitamin Derivatives
APPLICATION
Alfacalcidol: A Prodrug of Calcitriol, the Active Form of Vitamin D3
Alfacalcidol (1α-hydroxyvitamin D3) is a prodrug of calcitriol (1α,25-dihydroxyvitamin D3) [C3078] which is the active form of vitamin D3 (cholecalciferol) [
C0314]. The natural supply of vitamin D3 in human being mainly depends on ultraviolet light for conversion of 7-dehydrocholesterol [CAS: 434-16-2] to vitamin D3 in the skin. The transformation (hydroxylation at position 25) of vitamin D3 is catalyzed by enzymes in the liver and the kidney to produce calcitriol. Calcitriol is active in the regulation of the absorption of calcium from the gastrointestinal tract.
However, alfacalcidol is rapidly hydroxylated to calcitriol in the liver, effectively bypassing the critical renal metabolic conversion. Therefore, alfacalcidol is effective for patients with chronic renal failure to remedy vitamin D3 deficiency, and to increase the bone resorption and the bone formation. (The product is for research purpose only.)
PUBCHEM SUBSTANCE ID
354335206.0
BEILSTEIN/REAXYS NUMBER
2064794.0
HAZARD STATEMENTS
H300 + H310 + H330 : Fatal if swallowed, in contact with skin or if inhaled.
PRECAUTIONARY STATEMENTS
P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P262 : Do not get in eyes, on skin, or on clothing.
P271 : Use only outdoors or in a well-ventilated area.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing.
P284 : Wear respiratory protection.
P362 : Take off contaminated clothing and wash before reuse.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P302 + P350 + P310 : IF ON SKIN: Gently wash with plenty of soap and water. Immediately call a POISON CENTER or doctor/ physician.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
P405 : Store locked up.
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
QUALITY CERTIFICATION / COMPLIANCE
Fukaya factory is certified for GMP, ISO14001:2004 (JQA-EM5386) and IQ Net (JP-JQA-EM5386).
APPEARANCE
White to Almost white powder to crystal
MOLECULAR FORMULA
C27H44O2
PURITY (HPLC)
min. 95.0 area%
PURITY / ANALYSIS METHOD
>95.0%(HPLC)
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