MEK7 Antibody (pThr275): FITC

Polyclonal

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Canada

WB, AM

https://www.ncbi.nlm.nih.gov/gene/5609

NP_660186

Non-hazardous

Non-hazardous

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

WB (1:250); optimal dilutions for assays should be determined by the user.

Rabbit

Human

FITC

Peptide Affinity Purified

ISO 9001:2015

MEK7 (pThr275)

A phospho-specific peptide corresponding to residues surrounding Thr275 of human MKK7 (AA272-278)

Detects 47.485 kDa.

PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated

https://antibodyregistry.org/search.php?q=AB_2708915

Nucleus | Cytoplasm

Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

Immunology | Innate Immunity | Macrophage | Cell Signaling | Protein Phosphorylation | Serine / Threonine Kinases | MAPK Pathway | Cell Signaling | Metabolism | Redox Metabolism | Metabolism and Oxidative Stress

c-Jun N-terminal kinase kinase 2 antibody, Dual specificity mitogen activated protein kinase kinase 7 antibody, JNK activating kinase 2 antibody, JNK kinase 2 antibody, JNKK 2 antibody, Jnkk2 antibody, MAP kinase kinase 7 antibody, MAP2K7 antibody, MAPK/ERK kinase 7 antibody, MAPKK 7 antibody, MEK 7 antibody, Mitogen Activated Protein Kinase kinase 7 antibody, MP2K7_HUMAN antibody, PRKMK 7 antibody, SAPK kinase 4 antibody, SAPKK-4 antibody, SAPKK4 antibody, Sek 2 antibody, Sek-2 antibody, SKK4 antibody, stress-activated protein kinase kinase 4 antibody