LYN Antibody (pTyr508): ATTO 488

Polyclonal

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Canada

WB, AM

https://www.ncbi.nlm.nih.gov/gene/4067

NP_002341

Non-hazardous

Non-hazardous

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

WB (1:250); optimal dilutions for assays should be determined by the user.

Rabbit

Human

ATTO 488

Peptide Affinity Purified

ISO 9001:2015

LYN (pTyr508)

A phospho-specific peptide corresponding to residues surrounding Tyr508 of human Lyn (AA505-511)

Detects 58.443 kDa.

PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated

https://antibodyregistry.org/search.php?q=AB_2708617

Cell membrane | Nucleus | Cytoplasm

Widely expressed in a variety of organs, tissues, and cell types such as epidermoid, hematopoietic, and neuronal cells. Expressed in primary neuroblastoma tumors.

LYN is a protein-tyrosine kinase. It is involved in regulation of innate and adaptive immune response, cell degranulation and hematopoiesis. It is also involved in signal transduction induced by growth factors, cytokines and integrin signalling. It also responds to DNA damage and genotoxic agents. Its regulations many aspects of the cell depending on cell type and context. Lyn has been associated with increase in invasiveness and mestasis of breast cancer cells.

Cell Signaling | Protein Phosphorylation | Tyrosine Kinases | Src Family

AA407514 antibody, Hck 2 antibody, JTK 8 antibody, Lck/Yes related novel protein tyrosine kinase antibody, LYN antibody, LYN_HUMAN antibody, p53Lyn antibody, Tyrosine protein kinase LYN antibody