JAK2 Antibody (pTyr570)

Polyclonal

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Canada

WB, AM

https://www.ncbi.nlm.nih.gov/gene/3717

NP_004963

Non-hazardous

Non-hazardous

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

WB (1:250); optimal dilutions for assays should be determined by the user.

Rabbit

Human

Unconjugated

Peptide Affinity Purified

ISO 9001:2015

JAK2 (pTyr570)

A phospho-specific peptide corresponding to residues surrounding Tyr570 of human JAK2 (AA567-573)

Detects 130.674 kDa.

PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated

https://antibodyregistry.org/search.php?q=AB_2708399

Endomembrane system | Nucleus

Expressed in blood, bone marrow and lymph node.

JAK2 is a non-receptor protein-tyrosine kinase. Involved in cellular responses to growth factors and cytokines such as IL-3, GM-CSF and erythropoietin. Phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates receptor bound STATs, which then form homo- or heterodimers and migrate to the nucleus to activate gene transcription.

Cancer | Cell Cycle | Cell Cycle Inhibitors | Cell Signaling | Protein Phosphorylation | Tyrosine Kinases | Cell Signaling | Epigenetics and Nuclear Signaling | Nuclear Signaling Pathways | STATs | Cancer | Tumor Biomarkers | Oncoproteins | Signal Transducers

JAK 2 Antibody, JAK-2 Antibody, JAK2_HUMAN Antibody, Janus Activating Kinase 2 Antibody, JTK 10 Antibody, kinase Jak2 Antibody, THCYT3 Antibody, Tyrosine protein kinase JAK2 Antibody