Wortmannin

Small Molecules

Inhibitor

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Canada

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Non-hazardous

Non-hazardous

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

White to off-white solid.

≥98%

ISO 9001:2015

Wortmannin is a steroid metabolite from the fungi Penicillium funiculosum. It specifically and irreversibly inhibits phosphatidylinositol 3-kinase (PI3-K). This in turn has been shown to inhibit the metabolic effects of insulin, yet the insulin receptor kinase activity is not altered. Because PI3-K is involved in membrane trafficking, and membrane trafficking is important in autophagy, Wortmannin also inhibits autophagy.

1. Powis G., et al. (1994). Cancer Res. 54(9): 2419-23. 2. Hazeki O., et al. (1996). J Lipid Mediat Cell Signal. 14(1-3): 259-61. 3. Lee A., et al. (1995). FEBS Lett. 361(1): 51-4. 4. Blommaart E. F., et al. (1997). Eur J Biochem. 243(1-2): 240-6.

Cancer | Autophagy

SL-2052, KY12420