Specifications
SHIPPING NOTES
Shipped Ambient. All orders received in North America by 12:00 PM PST Monday to Thursday will usually be shipped out on the same day. North American customers will typically receive their orders within 1-2 business days. All shipments are F.O.B. from point of shipment, pre-paid and added to the invoice. Freight charges include but not limited to: priority service and packaging materials.Products are shipped with “cold packs” in insulated containers. There is a charge for this packaging and for the shipping costs via FedEx. Please inspect packages immediately upon receipt and inform Labscoop Customer Support of any shortage or damage within 48 hours of receipt. We can only accept returns after we have given prior authorization and issued specific shipping instructions. If a customer wishes to use their own FedEx account number please indicate this on the purchase order or during checkout.
SMILES
CCOC(=O)C1=C(N(N=C1)C2=CC=C(C=C2)NC(=O)C(=C(Cl)Cl)Cl)C(F)(F)F
INCHI KEY
RZHGONNSASQOAY-UHFFFAOYSA-N
*USAGE / SAFETY STATEMENT
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
QUALITY CERTIFICATION / COMPLIANCE
ISO 9001:2015
SCIENTIFIC BACKGROUND
Pyr3, a novel pyrazole, selectively inhibits TRPC3 channels. In B lymphocytes, Pyr3 eliminated the B cell receptor-induced Ca2+ oscillation regulated by TRPC3-mediated Ca2+ influx. In the cardiac system, Pyr3 attenuates activation of nuclear factor of activated T cells and hypertrophic growth in myocytes and pressure overloaded-induced hypertrophy in vivo (1).
REFERENCES
1. Kiyonaka S., Kato K., Nishida M., and Mori Y. (2010) Yakugaku Zasshi. 130(3): 303-311.
RESEARCH AREA
Neuroscience | Ion Channels | Transient Receptor Potential (TRP) Channels
ALTERNATIVE NAMES
Ethyl 1-{4-[(2,3,3-trichloroacryloyl)amino]phenyl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
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