Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. [UniProt]

Shipping & Handling

Shipped In

Cold Packs

Safety & Storage

Storage Temperature

Store the TLE1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Safety Statement

This TLE1 antibody is available for research use only.

Regulatory & Compliance

Technical Documents

Datasheet (1)

nwGvitle1-antibody-tlep1-1-v3890

Specifications

CLASS

Primary Antibodies

SUBCLASS

Monoclonal

UNIPROT ID

Q04724

CLONE NUMBER

TLEP1-1

*USAGE / SAFETY STATEMENT

This TLE1 antibody is available for research use only.

FORMAT

Purified (Sodium Azide Free)

APPLICATION.1

IHC-P, WB

HOST SPECIES

Mouse

ISOTYPE

Mouse IgG2a, kappa

REACTIVITY SPECIES

Human

CLONALITY

Monoclonal (mouse origin)

PURIFICATION

Protein G affinity chromatography

IMMUNOGEN

A portion of amino acids 175-338 from the human protein was used as the immunogen for the TLE1 antibody.

STORAGE BUFFER

1 mg/ml in 1X PBS; BSA free, sodium azide free

APPLICATION DETAILS

Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT

APPLICATION NOTES

The stated application concentrations are suggested starting points. Titration of the TLE1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

LOCALIZATION

Nuclear