NKX2.2 Antibody
SKU / CAT#: V3668IHC-7ML
$49900
usd
$71.29/ML
V3668IHC-7ML

NKX2.2 Antibody

NSJ Bioreagents
SKU / CAT#: V3668IHC-7ML
MPN: V3668IHC-7ML
$49900
usd
$71.29/ML
Available
SHIPS May 16th
Available
SHIPS May 16th
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Description
Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. Antibody to NKX2.2 detects a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. Antibody to NKX2.2 detects a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Store the recombinant NKX2.2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Safety Statement
This recombinant NKX2.2 antibody is available for research use only.
Regulatory & Compliance
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Specifications
CLASS
Primary Antibodies
SUBCLASS
Recombinant Monoclonal
GENE ID
https://www.ncbi.nlm.nih.gov/gene/4821
CLONE NUMBER
NX2/2198R
*USAGE / SAFETY STATEMENT
This recombinant NKX2.2 antibody is available for research use only.
FORMAT
Purified
APPLICATION.1
IHC-P
HOST SPECIES
Rabbit
ISOTYPE
Rabbit IgG, kappa
REACTIVITY SPECIES
Human
CLONALITY
Recombinant Rabbit Monoclonal
PURIFICATION
Protein A affinity chromatography
IMMUNOGEN
A human partial recombinant protein (within amino acids 1-119) was used as the immunogen for this recombinant NKX2.2 antibody.
STORAGE BUFFER
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
APPLICATION DETAILS
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
APPLICATION NOTES
Titering of the recombinant NKX2.2 antibody may be required for optimal performance.<br><br>1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
LOCALIZATION
Nuclear
Questions & Answers (0)
Citations (0)
IHC testing of FFPE Ewings sarcoma with recombinant NKX2.2 antibody (clone NX2/2198R). HIER: steam sections in 10mM citrate buffer, pH 6.0, for 10-20 min.
IHC testing of FFPE Ewings sarcoma with recombinant NKX2.2 antibody (clone NX2/2198R). HIER: steam sections in 10mM citrate buffer, pH 6.0, for 10-20 min.
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Store the recombinant NKX2.2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Safety Statement
This recombinant NKX2.2 antibody is available for research use only.
Regulatory & Compliance
Badge
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