SHP2 Antibody
SKU / CAT#: R30279
$41900
usd
$4.19/UG
R30279

SHP2 Antibody

NSJ Bioreagents
$41900
usd
$4.19/UG
Available
SHIPS May 5th
Available
SHIPS May 5th
SKU
Unit size / Options
Availability
Price
No products found
Description
The tyrosine phosphatase SHP2 is recruited into tyrosine-kinase signalling pathways through binding of its two amino-terminal SH2 domains to specific phosphotyrosine motifs, concurrent with its re-localization and stimulation of phosphatase activity. It can potentiate signalling through the MAP-kinase pathway and is required during early mouse development for gastrulation. SHP2 is specifically required in mesenchyme cells of the progress zone(PZ), directly beneath the distal ectoderm of the limb bud. Rather than integrating proliferative signals, it probably exerts its effects on limb development...
The tyrosine phosphatase SHP2 is recruited into tyrosine-kinase signalling pathways through binding of its two amino-terminal SH2 domains to specific phosphotyrosine motifs, concurrent with its re-localization and stimulation of phosphatase activity. It can potentiate signalling through the MAP-kinase pathway and is required during early mouse development for gastrulation. SHP2 is specifically required in mesenchyme cells of the progress zone(PZ), directly beneath the distal ectoderm of the limb bud. Rather than integrating proliferative signals, it probably exerts its effects on limb development...
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
After reconstitution, the SHP2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Safety Statement
This SHP2 antibody is available for research use only.
Regulatory & Compliance
Badge
Technical Documents
Specifications
CLASS
Primary Antibodies
SUBCLASS
Polyclonal
UNIPROT ID
Q06124
*USAGE / SAFETY STATEMENT
This SHP2 antibody is available for research use only.
FORMAT
Antigen affinity purified
APPLICATION.1
WB, IHC-P
HOST SPECIES
Rabbit
ISOTYPE
Rabbit IgG
REACTIVITY SPECIES
Human
CLONALITY
Polyclonal (rabbit origin)
PURIFICATION
Antigen affinity
IMMUNOGEN
An amino acid sequence from the C-terminus of human SHP2 (EDSARVYENVGLMQQ) was used as the immunogen for this SHP2 antibody (100% homologous in human, mouse and rat).
STORAGE BUFFER
0.5mg/ml if reconstituted with 0.2ml sterile DI water
APPLICATION DETAILS
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml
APPLICATION NOTES
The stated application concentrations are suggested starting amounts. Titration of the SHP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
BUFFER
Lyophilized from 1X PBS with 2% Trehalose
Questions & Answers (0)
Citations (0)
IHC-P: SHP2 antibody testing of human thyroid cancer tissue
IHC-P: SHP2 antibody testing of human thyroid cancer tissue
Western blot testing of SHP2 antibody and Jurkat cell lysate. Predicted molecular weight: ~68 kDa.
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
After reconstitution, the SHP2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Safety Statement
This SHP2 antibody is available for research use only.
Regulatory & Compliance
Badge
Science SamplesWe’re currently in BETA - Interested in joining? Let us know and we’ll get you set up with early access.

Join Our List

mail
Subscribe to the Scoop blog and get the latest updates on life in the lab.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Related Blog Articles
Related Blog Articles