This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results...
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results...
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Aliquot the Splicing factor 3B subunit 1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Safety Statement
This Splicing factor 3B subunit 1 antibody is available for research use only.
This Splicing factor 3B subunit 1 antibody is available for research use only.
FORMAT
Purified
APPLICATION.1
IHC-P, WB
HOST SPECIES
Rabbit
ISOTYPE
Rabbit Ig
REACTIVITY SPECIES
Human, Mouse
CLONALITY
Polyclonal (rabbit origin)
PURIFICATION
Antigen affinity purified
IMMUNOGEN
A portion of amino acids 374-402 from the human protein was used as the immunogen for the Splicing factor 3B subunit 1 antibody.
STORAGE BUFFER
In 1X PBS, pH 7.4, with 0.09% sodium azide
APPLICATION DETAILS
Immunohistochemistry (FFPE): 1:25, Western blot: 1:500-1:2000
APPLICATION NOTES
The stated application concentrations are suggested starting points. Titration of the Splicing factor 3B subunit 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
LOCALIZATION
Nuclear
Questions & Answers (0)
Citations (0)
+1
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Aliquot the Splicing factor 3B subunit 1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Safety Statement
This Splicing factor 3B subunit 1 antibody is available for research use only.
Regulatory & Compliance
We’re currently in BETA - Interested in joining? Let us know and we’ll get you set up with early access.
We’re currently in BETA - Interested in joining? Let us know and we’ll get you set up with early access.