Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta,...

Shipping & Handling

Shipped In

Cold Packs

Safety & Storage

Storage Temperature

Aliquot the HSD17B10 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Safety Statement

This HSD17B10 antibody is available for research use only.

Regulatory & Compliance

Technical Documents

Datasheet (1)

MVvlBhsd17b10-antibody-f54513

Specifications

CLASS

Primary Antibodies

SUBCLASS

Polyclonal

UNIPROT ID

Q99714

*USAGE / SAFETY STATEMENT

This HSD17B10 antibody is available for research use only.

FORMAT

Purified

APPLICATION.1

WB, FACS, IHC-P, IF

HOST SPECIES

Rabbit

ISOTYPE

Rabbit Ig

REACTIVITY SPECIES

Human, Mouse, Rat

CLONALITY

Polyclonal (rabbit origin)

PURIFICATION

Antigen affinity purified

IMMUNOGEN

Recombinant human protein was used as the immunogen for the HSD17B10 antibody.

STORAGE BUFFER

In 1X PBS, pH 7.4, with 0.09% sodium azide

APPLICATION DETAILS

Western blot: 1:500-1:2000, Flow cytometry: 1:25 (1x10e6 cells), Immunohistochemistry (FFPE): 1:25, Immunofluorescence: 1:25

APPLICATION NOTES

The stated application concentrations are suggested starting points. Titration of the HSD17B10 antibody may be required due to differences in protocols and secondary/substrate sensitivity.