NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. [UniProt]

Shipping & Handling

Shipped In

Cold Packs

Safety & Storage

Storage Temperature

Store the SIRT6 antibody at -20°C.

Safety Statement

This SIRT6 antibody is available for research use only.

Regulatory & Compliance

Technical Documents

Datasheet (1)

KVmTIsirt6-antibody-6c9-d10-d3-f54008

Specifications

CLASS

Primary Antibodies

SUBCLASS

Monoclonal

UNIPROT ID

Q8N6T7

CLONE NUMBER

6C9-D10-D3

*USAGE / SAFETY STATEMENT

This SIRT6 antibody is available for research use only.

FORMAT

Purified

APPLICATION.1

WB, ICC/IF, IP

HOST SPECIES

Mouse

ISOTYPE

Mouse IgG1

REACTIVITY SPECIES

Human, Mouse, Rat, Primate

CLONALITY

Monoclonal (mouse origin)

PURIFICATION

Protein G affinity

IMMUNOGEN

A human recombinant protein was used as the immunogen for this SIRT6 antibody.

STORAGE BUFFER

Antibody in PBS with 50% Glycerol and 0.03% ProClin 300

APPLICATION DETAILS

Western blot: 1:500,ICC/Immunofluorescence: 1:100,Immunoprecipitation: suitable

APPLICATION NOTES

The stated application concentrations are suggested starting points. Titration of the SIRT6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.