Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
Specifications
COUNTRY OF ORIGIN
China
GENE ID
https://www.ncbi.nlm.nih.gov/gene/7786;
*USAGE / SAFETY STATEMENT
For laboratory research and development purposes only.
APPLICATION.1
IHC
ANTIBODY TYPE
Polyclonal
HOST SPECIES
Rabbit
REACTIVITY SPECIES
Hu Ms Rt
PURIFICATION
Antigen affinity purification.
GENE ALIAS
MAP3K12
IMMUNOGEN
Fusion protein corresponding to a region derived from internal residues of human mitogen-activated protein kinase kinase kinase 12
SPECIFICITY
The antibody detects endogenous levels of total MAP3K12 protein.
SWISS-PROT NO.
Q12852
BACKGROUND
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.
ALTERNAME
DLK; MUK; ZPK; ZPKP1; MEKK12
FORM OF ANTIBODY
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
RECOMMENDED DILUTIONS
Immunohistochemistry: 1:25-1:100
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Citations (0)
Shipping & Handling
Shipped In
Cold Packs
Safety & Storage
Storage Temperature
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Safety Statement
For laboratory research and development purposes only.
Regulatory & Compliance
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